Vexpinem 500 Description

Imipenem + Cilastatin: A white to light yellow crystalline powder.
Each vial contains: Sterile Imipenem USP Eq. to Imipenem Anhydrous 500 mg, Sterile Cilastatin Sodium USP Eq. to Cilastatin Anhydrous 500 mg (A sterile mixture of Imipenem, Cilastatin sodium and Sodium Bicarbonate).
Imipenem and Cilastatin for Injection is a sterile mixture of Imipenem (a thienamycin antibiotic) and Cilastatin sodium (the inhibitor of the renal dipeptidase, dehydropeptidase 1), with sodium bicarbonate added as a buffer. Imipenem and Cilastatin is a potent broad spectrum antibacterial agent for intravenous administration.
Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by Streptomyces cattleya. Its chemical name is (5R, 6S)-3-[[2-(formimidoylamino)ethyl]thio]-6-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate. It is an off-white, nonhygroscopic crystalline compound with a molecular weight of 317.37. It is sparingly soluble in water and slightly soluble in methanol.
Cilastatin sodium is a white to tan-colored powder. Soluble in water and in methanol.
Its chemical name is 2-Heptenoic acid, 7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-, monosodium salt, [R-[R*,S*-(Z)]]-.
Sodium (Z)-7-[[(R)-2-amino-2-carboxyethyl]thio]-2-[(S)-2,2-dimethylcyclopropanecarboxamido]-2-heptenoate. It has molecular weight is 380.44.